Micky van de Ven Double Ends The Toffees' Run at New Stadium
Micky van de Ven emerged as the first backline player to score twice in a Premier League game for Tottenham since the Belgian defender in March 2013.
Key points
Micky Van de Ven nods home twice in first half
Everton's defender has equalizer disallowed after VAR review
Pape Matar Sarr scores final goal in 89th minute
This loss is Everton's initial at Hill Dickinson Stadium
Micky van de Ven scored on two occasions as Spurs extended their unbeaten run on the road in the Premier League and handed the Toffees their first defeat at their new home.
Everton were unbeaten in their five previous fixtures at their new ground at the dockside location, having left Goodison Park behind after more than a century at the conclusion of last season.
But Spurs captain the Dutchman pounced twice from corners in the first half to put their strong form at risk, and they were unable to mount a comeback before the midfielder - assisted by former Toffees attacker the Brazilian - nodded in a final goal to put the game to bed.
Jake O'Brien believed he had equalized the tally five minutes after Van de Ven's first goal, glancing a bullet header past Guglielmo Vicario from an set-piece.
Beto, in the meantime, missed a number of opportunities, while the Italian goalkeeper made a succession of fine stops to ensure the London club went five away games without defeat in the English top flight.
But the video assistant referee stepped in, advising the match official to check the goal on the screen and the official decided that Jack Grealish and Iliman Ndiaye were in offside positions and had interfered with the Spurs keeper.
This victory moves Thomas Frank's team into third place in the division, a handful of points off north London rivals and table-toppers the Gunners.
Everton remain 14th and are half a dozen points clear of the relegation zone.
Spurs breakdown: Van de Ven excels in duties at both ends of the field
Following a uninspiring midweek performance in the Champions League against the French side, where they managed a only attempts on goal, the manager chose the French striker in attack instead of ex-Everton forward the Brazilian.
The summer signing was unable to influence the game before being replaced for Richarlison after an hour on the field, but it emerged he wasn't needed in the final outcome.
Defender the Dutchman transformed into an attacking force to be feared.
Tottenham's first goal came from a cleverly executed set-piece play, with the midfielder directing the ball back across the face of goal for an unmarked Van de Ven to score.
And the captain - stepping up as captain in Cristian Romero's absence - added his second in added time as he rose above the England keeper to nod in.
Van de Ven was just as outstanding in defensive duties, partnering well with Kevin Danso as the duo handled excellently with the numerous deliveries thrown their way by the opposition.
Everton analysis: Toffees lacking striker's instinct
The club's new home had been a fortress, but it seems the freshness may have worn off slightly and fans headed to the exits after the midfielder's third for Tottenham.
The end in the team's winning streak at home won't be a massive worry for David Moyes, but their striker situation will be.
The forward and Thierno Barry - the Toffees' two established strikers - had netted only a single goal between them before Sunday's outing.
And they were unable to contribute to that miserable tally on a damp and dreary night on Merseyside.
The striker's form was summed up when he chose to overhead kick a clear chance from near the goal, even with having room and time to reposition for a simpler attempt that would have tested Vicario.
The substitute, too, failed to make an impact after replacing the starter in the second half.
It wasn't for a lack of opportunity. Most of Everton's attacks came through the winger and the forward, who tirelessly whipped dangerous balls into the Tottenham box.
What next for both teams?
The Toffees: Moyes' men head to the Stadium of Light in the Premier League on Monday, 3 November at 20:00 GMT.
Spurs: The London club travel to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup tie against Newcastle.